ANEMIA HEMOLITIK AUTOIMUN ADALAH PDF

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person’s own red blood cells (RBCs) cause them to burst (lyse), leading to. Autoimmune hemolytic anemia (AIHA) is an uncommon disorder characterized by hemolysis mediated by autoantibodies directed against. Autoimmune hemolytic anemia is characterized by shortened red blood cell survival and a positive Coombs test. The responsible autoantibodies may be either.

Author: Malalrajas Kijar
Country: Bangladesh
Language: English (Spanish)
Genre: Education
Published (Last): 3 November 2005
Pages: 464
PDF File Size: 16.26 Mb
ePub File Size: 4.13 Mb
ISBN: 321-9-91086-379-6
Downloads: 53715
Price: Free* [*Free Regsitration Required]
Uploader: Nikogal

In CAS, red cell transfusions are only indicated when there is a life-threatening anemia causing crisis. The traditional treatment of warm AIHA was the use of corticosteroid as first-line therapy and conventional immunosuppressive drugs such as azathioprine and cyclophosphamide, or surgical splenectomy as second-line therapy in patients with insufficient response to corticosteroid.

Cold autoantibody type A. Healthy individuals often display low-titer cold agglutinins, but in chronic cold agglutinin disease, serum titers may range from 1: RBC transfusion would be an effective supporting treatment option as heemolitik bridge heomlitik.

However, if hemolitlk presents within the first two years of life or in the teenage years, the disease often follows a more chronic courserequiring long-term immunosuppressionwith serious developmental consequences. The automiun cell eluate typically indicates panreactive warm IgG autoantibody.

Nearly half of all warm antibody AIHA patients have autoantibodies specific for epitopes on Rh proteins [ 29303132 ]. Congenital or tertiary syphilis in adults III. Life-threatening, antiglobulin test-negative, acute autoimmune hemolytic anemia due to a non-complement-activating IgG 1k cold antibody with Pr a specificity.

Anemia Hemolitik Autoimun by erfan andrianto on Prezi

The most common causes of secondary warm-type AIHA include lymphoproliferative disorders e. Associated with the rheumatic disorders, e.

  LAS ILUMINACIONES RIMBAUD PDF

Some of the patients with warm AIHA also possess a cold agglutinin. Idiopathic primary paroxysmal cold hemoglobinuria. Associated with certain nonlymphoid neoplasms e.

Diagnosis and treatment of autoimmune hemolytic anemia: classic approach and recent advances

Auto-immune haemolytic anaemia – a high-risk disorder for thromboembolism? IgG 4 autoantibodies against erythrocytes, without increased hemolysis: Specificity of acquired haemolytic anaemia autoantibodies and their serological characteristics. The hemolysis is self-limited, lasting weeks [ 3 ]. Secondary cold type AIHA is also caused primarily by lymphoproliferative disorders, but is also commonly caused by infection, especially by mycoplasma, viral pneumonia, infectious mononucleosis, and other respiratory infections.

A high index of suspicion on the part of the clinician and discussions with blood bank personnel can usually reveal the role of the drug. Drug-induced immune hemolysis may mimic warm or cold antibody AIHA, hereditary hemolytic anemias such as HS, and other drug-mediated hemolytic anemias such as glucosephosphate dehydrogenase deficiency.

Episodic hemolysis raises the possibility of paroxysmal cold hemoglobinuria, march hemoglobinuria, and PNH. Urinary urobilinogen is increased but bilirubin is not detected in the urine unless serum conjugated bilirubin is increased. Arndt PA, Garratty G. The prognosis in secondary warm antibody AHA largely depends upon the course of the underlying disease.

Open in a separate window. Most cases of PCH are self-limited. Children with chronic AIHA tend to be older [ 60 ]. The blood film exhibits several features common to all types of AIHA. In this case, splenectomy may be considered, as well as other immunosuppressive drugs. Monospecific antisera to IgM or IgA may be used in selected cases [ 1 ]. Autoimmunity, Hemolysis, Agglutinin, Hemolysin, Direct antiglobulin test.

  LAS ACTIVIDADES TURISTICAS Y RECREACIONALES ROBERTO BOULLON PDF

The direct antiglobulin reaction may be positive for complement during and briefly following an acute attack. Support Center Support Center. Graves’ disease Myasthenia gravis Pernicious anemia. User Username Password Remember me. To determine the autoantibody or autoantibodies present in a patient, the Coombs testalso known as the antiglobulin test, anemiq performed.

Autoimmune hemolytic anemia: From lab to bedside

Bull N Y Acad Med. This study found that the etiology of AIHA cold type were idiopathic or primary InBoorman, Dodd, and Loutit applied the direct antiglobulin gemolitik to a variety of hemolytic anemias, and laid the foundation for the clear distinction of autoimmune from congenital hemolytic anemia. But, often they exhibit reactivity against allogenic red cells. The immune haemolytic anaemias: Jaundice may be present.

Autoimmune hemolytic anemia: From lab to bedside

Less often a patient may note sudden onset of symptoms of severe anemia and jaundice over a few jemolitik. The peak incidence being between 60 and 70 years of age and the frequency of the disorder is usually more in females than in males.

Proc R Soc Med. Hematology of Infancy and Childhood. Anti-i specificity is predominant in patients with infectious mononucleosis and in some patients with lymphoma.

How I abemia autoimmune hemolytic anemias in adults. Hereditary aspects of autoimmune hemolytic anemia; a retrospective analysis. Classification of AIHA modified from [ 1 ]. Autoimmune hemolytic anemia and the Kell blood groups. No critical patient should be denied blood transfusion due to serological incompatibility.