Como antiarrítmico: • Dosis inicial de carga: 1,25 mg/kg i.v en infusión intermitente, cada 5 min. hasta un total de 15mg/kg. • Mantenimiento. calculo de dosis factor goteo regla de tres. CONECTAR A EQUIPO MACRO IV DIRECTA FENITOINA (EPAMIN) ANTICONVULSIVANTE. DIFENILHIDANTOINA (Fenitoina) Mecanismo de Acción: . en el hígado y el 35 % de una dosis oral aparece en la orina, vida media 4 h.

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The statistical confrontation was performed employing Mann-Whitney non-parametric test. To view content sources and attributions, please refer to our editorial policy.

The results showed that the average body weight of treated animals decreased. Histopathological and morphometric changes at all lingual regions were observed.

Services on Demand Journal. Due to the refractory characteristics of his seizures he was put on DFH mg dfenilhidantoina, and developed a pancerebellar syndrome. Phenytoin-Related cerebellar degeneration without seizures.

Long term anticonvulsant therapy and cerebellar atrophy. Nevertheless his neurological examination still showed trunkal and lower limbs ataxia. Actualizar las hipotesis planteadas en su patogenia.

Histological aspects of the epithelium of tongue’s posterior region of control group a and phenytoin treated group b. Saunders,Vol 4, No 3, p.

Harald Masur 8 Estimated H-index: Other Papers By First Author. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.


The morphometric parameters were estimated using drawings 50 sketches made on paper and then measured using a millimetric scale, obtained with the aid of a light camera JENA, with final magnification X. Number of Purkinje’s cells after diphenylhydantoin intoxication in pigs.

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After one year of follow up his neurological picture did not change, while he was seizures free. Home International Fenitoina Print Share.

Phenytoin – induced cleft palate: Several mechanisms have been described, with the attempt to explain the changes observed here and also those reported in literature.

The prickle-cell and basal layer showed to be disorganized; the granular layer was absent as well as the horny layer, consequently Fig. The epithelium of the ventral tongue region of control animals showed to be thicker than that of treated animals Fig. One should remember that phenytoin acts in the fetus of rats and mice, decreasing DNA synthesis, as well as protein synthesis Netzloff et al.

Cerebellar atrophy and persistent cerebellar ataxia after acute intoxication of phenytoin. Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity. Psychiatr Clin Kaeko Kitamura 1 Estimated H-index: Neme 1 Estimated H-index: In the anterior dorsal region of the tongue, the epithelium showed to be less thick, with no papilla; the cells from the prickle-cell and basal layer showed to be more rounded and morphologically very alike, and their nuclei showed loose chromatin, evident nucleolus, and two-nucleolus nuclei were often observed.


How to cite this article. Sodium diphenylhydantoinate in treatment of convulsive disorders.

For both cases, the malformations are preceded by the same precocious pathological changes difeniohidantoina, vascular breach, hemorrhage and at last tissue necrosis during the same pregnancy phase. Porter RJ, Theodore W. Cerebellar degeneration with epilepsy.

Prenatal exposure to phenytoin, facial development and, a possible role for vitamin K. Parenchymatous cerebellar degeneration complicating diphenylhydantoin Dilontin therapy.


Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Consult with your healthcare professional before taking any medication. In order to support the hypoxia hypothesis, the malformations induced by the phenytoin are almost all identical to those, which can be observed after uterine vessels clampage.

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